Study demonstrates SARS-CoV-2 ORF6 localization and interferon antagonism as independent events
The severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) antagonizes interferon (IFN)-mediated host defenses for infection establishment. SARS-CoV-2 nucleocapsid proteins further enhance its pathogenicity by suppressing IFN signaling to various degrees, with the open reading frame 6 (ORF6) protein being the strongest IFN antagonist.
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https://www.news-medical.net/news/20211212/Study-demonstrates-SARS-CoV-2-ORF6-localization-and-interferon-antagonism-as-independent-events.aspx