Unveiling the role of Daam1 gene in intestinal stem cell fate decisions
Stem cells can differentiate to replace dead and damaged cells. But how do stem cells decide which type of cell to become in a given situation? Using intestinal organoids, the group of Bon-Kyoung Koo at IMBA and the Institute for Basic Science identified a new gene, Daam1, that plays an essential role, switching on the development of secretory cells in the intestine. This finding, published on November 24 in Science Advances, opens new perspectives in cancer research.

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